Liposome Calculator 5.9
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Paid Version
Publisher Description
Liposome Calculator helps in preparation of liposome solutions. Components concentrations (molarity and mg/ml) and moles, and volumes of stock solutions are calculated based upon data provided, such as: initial concentrations of the stock solutions, and required molar ratios.
Application is comprised of two activities: First is Calculator, that helps to parameterize and prepare the complex suspension systems. Second is Analyzer that helps in analysis of liposome parameters, such as number of molecules per vesicle, inner, entrapped volume and encapsulation.
The Calculator follows the common liposome preparation procedure (volard.wordpress.com):
1. Stock solutions of lipids (or any other compound) are mixed in appropriate molar ratios.
2.Obtained mixture is purged with nitrogen and organic solvent is finally evacuated under vacuum.
3.Obtained lipid mixture is hydrated and extruded or sonicated, according to the needs.
Calculator features:
Unlimited number of components is available. Additional components are added by touching “Solution# (+)” field and deleted by touching the “Molar% (-)” field.
Application is fully interactive: all system parameters are updated immediately after any input from user (if it is sufficient!). For example: final molar concentration and molar ratios of the components can be adjusted at any time if molar concentrations of starting solutions and final suspension volume are provided. Upon any of the aforementioned changes, the application will calculate the volumes of the initial solutions to fit the desired parameters.
The database is used to store compounds data, that will be available to autocomplete upon typing compounds' names in the main calculator.
Important points.
Sum of stock solution volumes doesn't have to be equal to final suspension volume (Refer to the procedure)!
Watch out the molar ratios to ensure that all starting components are included! Program will expel components for which insufficient data is provided! Thus, for example concentration in g/l cannot be included in calculations if Mw of solute is not provided.
Liposome Analysis Activity Layout:
The activity window divided to data panel (left) and results panel (right).
The data panel parameters:
Total Concentration: Total lipid concentration. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Total Volume: Total solution volume. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Diameter: Average liposome outer diameter in nanometers (one billionth of meter).
Bilayer Thickness: Lipid bilayer thickness in angstroms.
Molecular Area: Single lipid molecule area in square angstroms.
The results panel parameters:
Number of Molecules: Average number of lipid molecules in a single liposome (vesicle).
Number of Liposomes: Average total number of liposomes in the analyzed solution.
Inner Volume: Average volume entrapped in a single liposome.
Surface Area: Average surface area of a single liposome.
Encapsulation Efficiency: In this context is represented by ratio of the total entrapped volume to total solution volume. Look up for the definition in regards to the drug encapsulation.
Important Points.
Usage of high total concentrations (particularly in molar range) leads to an inappropriate system analysis (encapsulation efficiency values exceeding 100%), since physical state of system cannot anymore be considered as a dilute vesicle suspension.
Aug 10, 2023
Version 5.9
Compatibility update.
About Liposome Calculator
Liposome Calculator is a paid app for iOS published in the Kids list of apps, part of Education.
The company that develops Liposome Calculator is Roman Volinsky. The latest version released by its developer is 5.9.
To install Liposome Calculator on your iOS device, just click the green Continue To App button above to start the installation process. The app is listed on our website since 2023-08-10 and was downloaded 1 times. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded app with your antivirus. Your antivirus may detect the Liposome Calculator as malware if the download link is broken.
How to install Liposome Calculator on your iOS device:
- Click on the Continue To App button on our website. This will redirect you to the App Store.
- Once the Liposome Calculator is shown in the iTunes listing of your iOS device, you can start its download and installation. Tap on the GET button to the right of the app to start downloading it.
- If you are not logged-in the iOS appstore app, you'll be prompted for your your Apple ID and/or password.
- After Liposome Calculator is downloaded, you'll see an INSTALL button to the right. Tap on it to start the actual installation of the iOS app.
- Once installation is finished you can tap on the OPEN button to start it. Its icon will also be added to your device home screen.
